Comparing CGRP blockers is the next big challenge for Migraine patients. Now that we have three new preventive options specifically designed for Migraine, we’re faced with that all-important question: Which one should we choose: Aimovig, Ajovy, or Emgality?
Which one works better?
It’s too soon to know if one treatment is more effective for any given situation. We just don’t know if one works better than others for specific types of Migraine, or certain populations based on age, gender, or comorbidities. Getting those answers will require years of observing patient responses to treatment.
David Watson, MD, shares his perspective on these new treatment options:
It is still way too early to determine which of these new medications is “better”, or even if there is real difference. Like most treatment options, what works for one person perfectly might not be so great for someone else. The big news here is that we have three new treatment options, all of which appear to be effective for preventing migraine attacks. That’s great news.
Other ways to compare
Until then, absent a recommendation from our doctors, the choice may be a matter of personal preference. Although very similar, there are slight differences. These differences may help us choose which one is right for us.
- Cost – All three are equally priced. However, coverage and co-pay costs from individual insurance plans may affect our choice. Each company’s assistance programs may affect our decision, too.
- Accessibility – Do we prefer a mail order or local pharmacy? How long must we wait to receive our medication? Will pharmacies stock each medicine equally?
- Convenience – Ease of storage can affect our decision, too. Some of these medications must be shipped and require a signature. Do we have the time and flexibility to accommodate this requirment? All three must be refrigerated until shortly before use and none can be exposed to high temperatures.
- Delivery Method – Some prefer auto-injectors while others would rather use a syringe. That personal preference must be taken into consideration when making a treatment choice.
- Dosing Schedule – Is once a month convenient enough, or would we rather choose a quarterly option? Some of us may need two or three doses, depending on the dosing schedule. Are we prepared for two injections? What about three?
- Side Effects – All three have the potential for injection site skin irritation. One may also cause constipation. If constipation is already a problem for us, we may decide to skip that one in favor of the other two. Also, because they’re all new, there may be side effects that didn’t appear in clinical trials. How comfortable are we with that unknown risk?
- Allergies – One treatment uses rubber tips derived from latex which could be a problem if we have a latex allergy. The other two do not use latex.
Take a closer look at how they all stack up against each other. Pay close attention to the variables that matter most.
Quarterly (3 doses)
Monthly (1 dose)
Upper arm (injection by others)
Upper arm (injection by others)
Upper arm or buttocks (injection by others)
Keep watching for more!
Remember that no medication works the same for everyone. If one of these choices doesn’t work, it may be worth trying another. No matter what, don’t give up. There are more options still to come!